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Date:
February 24, 2009
Source:
Duke University Medical Center
Summary:
A strain of laboratory mice that has "" powers has been found to resist inflammation after a knee injury, and also to avoid developing arthritis at the injury site in the long term, according to researchers. Their findings illuminate the mechanisms of post-traumatic arthritis and could point to therapies for this condition, which commonly afflicts younger people who lose productivity during their prime working years.
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A strain of laboratory mice that has "" powers has been found to resist inflammation after a knee injury, and also to avoid developing arthritis at the injury site in the long term, according to researchers at Duke University Medical Center. Their findings illuminate the mechanisms of post-traumatic arthritis and could point to therapies for this condition, which commonly afflicts younger people who lose productivity during their prime working years.

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"" said Steven A. Olson, MD, FACS, principal investigator of the post-traumatic arthritis project and chief of the Duke orthopaedic trauma section. ""

Olson said 10 percent of all arthritis cases - about 4.6 million - are post-traumatic arthritis patients, many of whom suffer for years and are too young for joint replacement surgeries. The economic cost thus is about $12.8 billion annually for this group, according to Arthritis Foundation statistics.

The scientists examined the differences in inflammatory response between two types of mice: one type known as superhealers (or MRL/MpJ) versus a strain of control mice (C57BL/6).

turmeric tea side effecthow to turmeric tea side effect for Previously, scientists discovered that the superhealer mice had such regenerative powers that holes made in their ears for lab identification purposes grew over completely with no sign of scar tissue. Earlier work done at Duke showed no differences between healthy and fractured limbs when the superhealers healed from a fracture of the the 1 last update 2020/06/02 knee joint.Previously, scientists discovered that the superhealer mice had such regenerative powers that holes made in their ears for lab identification purposes grew over completely with no sign of scar tissue. Earlier work done at Duke showed no differences between healthy and fractured limbs when the superhealers healed from a fracture of the knee joint.

"" said Bridgette Furman, research analyst and lead scientist of this study. ""

In the latest experiment, the team got very clear results in the genetic response within injured tissue: the control mice showed a greater than 700-fold increase in the expression of one cytokine, interleukin(IL-1β) in the first four hours after a fracture and 37-fold difference in that cytokine level at 7 days after the fracture. Cytokines are signaling molecules produced by cells in response to injury. Interleukin generally promotes inflammation and an increase in temperature. The superhealer mice showed a similar trend, but in much lower amounts: a 70-fold peak in expression at day 0 down to a 3.5-fold increase by day 7.

A second cytokine, TNF-α, was also expressed at a significantly higher rate in the control mice after the fracture (from a 13-fold peak just after fracture to 5-fold at 7 days), while the superhealer mice showed no change in their levels of TNF-α at all over time.

turmeric tea side effecthow to turmeric tea side effect for "" said Farshid Guilak, Ph.D., study scientist and director of the Orthopaedic Bioengineering Laboratory in the Duke Department of Surgery. ""

The team for 1 last update 2020/06/02 also studied the mice''s Disease

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  • The team also studied the mice''s Disease
  • Diseases and Conditions
  • Disability
  • Chronic Illness
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