rheumatoid lung disease treatment

🔥+ rheumatoid lung disease treatment 08 Aug 2020 Hip osteoarthritis is a joint disease that mostly affects your hip joint cartilage. Articular cartilage is the hard slippery surface that covers the ...

rheumatoid lung disease treatment ... 9 vitamins and supplements, backed by science, that help relieve arthritis pain. ... But more natural medicines are being put to the test in well-designed clinical ...

Menu
×

4.4.19 the 1 last update 2020/08/08 7:10AM4.4.19 7:10AM

rheumatoid lung disease treatmenthow to rheumatoid lung disease treatment for Susan Ince

4.4.19 7:10AM

Many people with AS have the HLA-B27 gene, but most people with the HLA-B27 gene never develop AS.

This video is part of a new campaign about ankylosing spondylitis (AS) awareness from the nonprofit patient community CreakyJoints. The videos in this campaign were produced with support from Novartis Pharmaceuticals Corporation. 

Ankylosing spondylitis (AS) is the most common form of spondyloarthritis, which is a family of arthritic diseases that affect the spine, sacroiliac joints, and the places where ligaments and tendons attach to bones (called entheses). In AS, inflammation primarily leads to pain and stiffness in the spine and the sacroiliac joints, which join for 1 last update 2020/08/08 the sacrum (base of the spine) with the pelvis. Ankylosing spondylitis (AS) is the most common form of spondyloarthritis, which is a family of arthritic diseases that affect the spine, sacroiliac joints, and the places where ligaments and tendons attach to bones (called entheses). In AS, inflammation primarily leads to pain and stiffness in the spine and the sacroiliac joints, which join the sacrum (base of the spine) with the pelvis.

AS has a strong genetic basis, and variations in several genes have been detected that influence the risk of developing this disorder. The strongest link by far is with HLA-B27; certain variations in the HLA-B27 gene are associated with development of AS. Usually HLA genes help your immune system in recognizing and presenting foreign invaders, such as viruses and bacteria, to the immune cells. Here’s what you need to know about HLA-B27.

What is HLA-B27 and how does it affect arthritis?

HLA-B is a gene that provides instructions for making a protein that sits on the surface of cells and helps your immune system determine which proteins it the 1 last update 2020/08/08 comes in contact with are from your own body and which are foreign and potentially dangerous, such as viruses and bacteria.HLA-B is a gene that provides instructions for making a protein that sits on the surface of cells and helps your immune system determine which proteins it comes in contact with are from your own body and which are foreign and potentially dangerous, such as viruses and bacteria.

There are hundreds of different forms of the HLA-B gene, designated by numbers. One of them, HLA-B27, is strongly associated with the development of ankylosing spondylitis.

“About 80 to 90 percent of [certain populations of] patients with AS are positive for HLA-B27, and in different populations the prevalence of AS mirrors the prevalence of HLA-B27,” says Abhijeet Danve, MD, assistant professor and director of the spondyloarthritis program at Yale University in New Haven, Connecticut. “How exactly HLA-B27 contributes to the pathogenesis of AS is not entirely clear but extensive work has been done in this regard and several theories have been suggested.”

HLA-B27 is also found in patients with other forms of spondyloarthritis such as psoriatic arthritis, inflammatory bowel disease, reactive arthritis in response to an infection, and isolated acute anterior uveitis (an inflammation of the middle layer of the eye which occurs in some people with autoimmune disorders such as AS), though the association of HLA-B27 with these diseases isn’t as strong as it is with AS.

Should I get a blood test for HLA-B27?

rheumatoid lung disease treatmenthow to rheumatoid lung disease treatment for Probably only if your doctor strongly suspects you could have AS, based on a constellation of AS symptoms, or signs of inflammatory back pain.

“We use HLA-B27 as a helpful test rather than a confirmatory test. I send it only in patients with back pain who also have other AS features such as gradual onset of chronic back pain that started before the age of 45, features suggesting inflammatory back pain, a history of heel pain or Achilles tendonitis, uveitis, psoriasis, or a family history of AS, psoriasis, or inflammatory bowel disease,” Dr. Danve says.

Why not just test everyone for HLA-B27? “Because about 7 percent of Americans are positive for HLA-B27 but only 5 to 10 percent of people with a positive HLA-B27 will have AS,” says Dr. Danve. The prevalence of positive HLA-B27 and the risk of developing AS is higher in people with a positive family history of AS, he says.

rheumatoid lung disease treatmenthow to rheumatoid lung disease treatment for If you don’t have AS symptoms but are found to be positive for HLA-B27, there’s nothing special that your doctor can do to lessen your chances of developing AS. “There is no data about preventive measures except that you should stop smoking, which is a known risk factor for progression in patients with known AS.”

While HLA-B27 is the genetic variation with the strongest link to AS, there may be tests on the horizon that do a better job at identifying people with the disease. While not yet commercially available, in a recent study from Australia risk scores that took thousands of genetic variations (each with a small impact) into account were better able to identify people with AS than HLA-B27 alone.

Can you have AS without being positive for HLA-B27?

rheumatoid lung disease treatmenthow to rheumatoid lung disease treatment for the 1 last update 2020/08/08

Yes. While, in general, populations with higher levels of HLA-B27 have higher rates of AS, the connection between HLA-B27 and AS isn’t the same in all ethnic groups. For example, a 2017 study published in Clinical Rheumatology found that black Americans had more severe symptoms than white patients but only 63 percent were positive for HLA-B27 (compared with 85 percent of white patients and 87 percent of Latinos).

People diagnosed at an early stage of AS, called non-radiographic axial spondyloarthritis, are also less likely to have HLA-B27, with just 50 to 75 percent of people testing positive, according to Dr. Danve.

Will being positive for HLA-B27 change my treatment or the likely course of my disease?

Your treatment is unlikely to change, but there are several ways that AS the 1 last update 2020/08/08 seems to differ in those who are HLA-B27 positive.Your treatment is unlikely to change, but there are several ways that AS seems to differ in those who are HLA-B27 positive.

“Patients with a positive HLA-B27 develop AS earlier, are diagnosed earlier, and are more likely to have a positive family history. Compared with other people who have AS, they are more likely to develop uveitis and less likely to have psoriasis or inflammatory bowel disease,” Dr. Danve says.

Use Our ArthritisPower App to Manage Your Arthritis

Join CreakyJoints’ patient-centered research registry and track AS symptoms like pain, fatigue, and more. Learn more and sign up here.Join CreakyJoints’ patient-centered research registry and track AS symptoms like pain, fatigue, and more. Learn more and sign up here.

Keep Reading

the 1 last update 2020/08/08   

Susan the 1 last update 2020/08/08 InceSusan Ince

Leave a Reply Cancel reply

rheumatoid lung disease treatmenthow to rheumatoid lung disease treatment for Your email address will not be published. Required fields are marked the 1 last update 2020/08/08 **

Coping with COVID-19 Through Art: Managing ‘Sadness in Chaos’

CreakyStaff
Read More

rheumatoid lung disease treatmenthow to rheumatoid lung disease treatment for COVID-19 Symptoms Added to CDC List: The 9 Coronavirus Signs That Should Be on Your Radar

rheumatoid lung disease treatmenthow to rheumatoid lung disease treatment for Barbara Brody
Read More

You Can Help Stop Anxiety by ‘Savoring a Good Feeling’ for 10 Seconds

Laurie Ferguson, PhD
Read More

How to Care for Your Nails at Home if You Have Psoriasis or Psoriatic Arthritis

Karyn Repinski
Read More

rheumatoid lung disease treatmenthow to rheumatoid lung disease treatment for Login / Register

Login to comment on posts, connect with other members, access special offers and view exclusive content.